We create technologies to enable high-titre, scalable viral vector production.
Gene Therapy at the edge of impossible
OXGENE offers a range of viral technologies including AAV, lentiviral and adenoviral vectors for license, as well as custom solutions to meet the manufacturing demands of new cell and gene therapies. Our suspension-mode transient viral manufacturing systems offer industry leading titres, quality and regulatory compliance. These, together with our inducible viral packaging and producer cell lines, address the industry-wide challenge of scalability, while our internal process development services can expedite on-boarding of technologies and facilitate technology transfer.
OXGENE technologies drive broad adoption of cell and gene therapies, addressing dosage requirements for treatment of large patient populations and systemic administration
OXGENE’s SnapFast™ plasmids are versatile and efficient. This proprietary technology enables us to generate large numbers of custom constructs by the systematic and simple transfer of DNA building blocks across a range of expression platforms.
We also offer an extensive index of pre-validated licensable plasmids for use in custom expression system development.
HEK293 Suspension Cell Lines (GMP-compliant)
OXGENE’s licensable GMP-compliant, clonal suspension HEK293 cell lines are validated for high-titre production of recombinant AAV (rAAV), lentiviral and adenoviral vectors. All cell lines offer full traceability, and grow in defined, animal component free media. Cell lines do not contain the SV40 Large-T antigen, which ensures regulatory compliance of derived products for in-vivo applications.
Our proprietary cell lines and optimised SnapFast™ plasmid systems combine to provide a cutting-edge solution for transient high titre viral vector production. We now have multiple partners using these platforms in their clinical development programs.
We aim to transition the gene therapy industry to new levels of scalability with GMP-compliant, suspension mode, stable packaging and producer HEK293 cell lines.