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Complex CRISPR Edits

Our in house expertise is supported by state-of-the-art automation to deliver in-frame tags, chromosomal rearrangements and deletions, and conditional KOs.

Validated clonal edits

We analyse selected clones with in-house bioinformatics software, before sending the final clonal cell line for full NGS analysis to confirm the edit before shipping.

CRISPR edited iPSCs

Our automated CRISPR engineering platform can reliably deliver CRISPR edited iPSC lines for advanced disease modelling.

OXGENE has considerable in-house expertise in genetically engineering mammalian cells as well as access to the latest CRISPR editing technology.

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Complex modifications

Many genetic diseases are the result of more than one gene knockout or other types of mutations entirely, and culturing primary cells from patients with these mutations can be very difficult. With the support of our  automated gene editing platform, our in-house experts  generate clonal cell lines modelling complex disease scenarios, including double knock-outs, conditional knock-outs, knock-ins, gene fusions and chromosomal  rearrangements.
 
We’ve also optimised our automated gene editing platform to accommodate high throughput edits of inducible Pluripotent Stem Cells (iPSCs). These are a particularly powerful tool for disease modelling and drug discovery, but can be challenging to work with, as they differentiate in response to cellular stress, and exhibit notoriously low editing efficiency. However, we’ve optimsied our gene editing workflow to achieve a careful balance between cellular stability and editing efficiency to deliver reliably edited iPSC lines. 
 

We put a strong emphasis on communication with our partners, who remain in direct contact with both the project manager and scientific team throughout the project.

Find out more about bespoke complex CRISPR engineering projects for disease modelling.

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