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Adenoviral expression systems

OXGENE offers bespoke adenoviral engineering and process development services, as well as our proprietary GMP compliant, suspension HEK293 and HEK293TetR cell line for amplification of cytotoxic adenoviral vectors.

OXGENE designs, assembles and produces adenoviral vectors of any genetic composition for pioneers, to facilitate both gene therapy and oncolytic applications.

HEK293TetR Cell Line

OXGENE's GMP compliant suspension HEK293TetR cell line is ideal for amplification of cytotoxic adenoviral vectors. We have demonstrated the functionality of this cell line through our partnership with Vaccitech, who will be using this cell line in clinical trials opening throughout 2020, and through partner CMOs. In all cases, this animal component and antibiotic free cell line outperformed commercial alternatives, demonstrates improved scalability and full stability in the absence of antibiotics and allows optimisation of adenoviral production even for transgenes that reduce cell viability.

See the latest data in our HEK293 cell line flyer.

Talk to our team to design, assemble and produce your adenovirus vectors

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Connex revolutionises DNA design, optimization and assembly by ensuring the highest levels of quality control, efficiency and project management available for any client.

OXGENE has fully integrated all its smart labs and robotic production processes within a single technology platform that allows real-time project updates for our customers.