Adenoviral expression systems
OXGENE offers bespoke adenoviral engineering and process development services, as well as our proprietary GMP compliant, suspension HEK293 and HEK293TetR cell line for amplification of cytotoxic adenoviral vectors.
OXGENE designs, assembles and produces adenoviral vectors of any genetic composition for pioneers, to facilitate both gene therapy and oncolytic applications.
HEK293TetR Cell Line
OXGENE's GMP compliant suspension HEK293TetR cell line is ideal for amplification of cytotoxic adenoviral vectors. We have demonstrated the functionality of this cell line through our partnership with Vaccitech, who will be using this cell line in clinical trials opening throughout 2020, and through partner CMOs. In all cases, this animal component and antibiotic free cell line outperformed commercial alternatives, demonstrates improved scalability and full stability in the absence of antibiotics and allows optimisation of adenoviral production even for transgenes that reduce cell viability.
See the latest data in our HEK293 cell line flyer.
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